By making full use of our technologies having developed over many years for fermentation, extraction, purification and others, we have been manufacturing the enzyme products for clinical diagnostic and others as one of biochemical materials, and have been providing contract manufacturing services regarding such enzyme products.
Enzyme list *
|Saccharide||Glucose dehydrogenase||188.8.131.52||D-Glucose + acceptor -> D-Glucono-1,5-lactone + reduced acceptor|
|Pyranose oxidase||184.108.40.206||D-Glucose + O2 -> 2-Dehydro-D-glucose + H2O2|
|D-Amino acid oxidase||220.127.116.11||D-Amino acid + H2O + O2 -> 2-Oxo acid + NH3 + H2O2|
|L-Amino acid oxidase||18.104.22.168||L-Amino acid + H2O + O2 ->
2-Oxo acid + NH3 + H2O2
(L-Phenylalanine + H2O + O2 -> Phenylpyruvic acid + NH3 + H2O2)
|Glycine oxidase||22.214.171.124||Glycine + H2O + O2 -> Glyoxylic acid + NH3 + H2O2|
|126.96.36.199||L-Kynurenine + NAD(P)H + H+ + O2
-> 3-Hydroxy-L-kynurenine + NAD(P)+ + H2O
|L-Tryptophan oxidase||-||L-Tryptophan + H2O + O2 -> Indole-3-pyruvic acid + NH3 + H2O2|
|Alanine racemase||188.8.131.52||L-Alanine <-> D-Alanine|
|beta-Cyanoalanine synthase||184.108.40.206||O-Acetyl-L-serine + HCN -> beta-Cyano-L-alanine + CH3COOH|
aminobutyric acid synthase
|220.127.116.11||O-Acetyl-L-homoserine + HCN
-> gamma-Cyano-alpha-aminobutyric acid + CH3COOH
|Tryptophanase||18.104.22.168||L-Tryptophan + H2O <-> Indole + Pyruvic acid + NH3|
|beta-Tyrosinase||22.214.171.124||L-Tyrosine + H2O <-> Phenol + Pyruvic acid + NH3|
|Carboxylic acid||Formate dehydrogenase||126.96.36.199||Formate + NAD+ <-> CO2 + NADH|
* Some of these products are under development.
Glucose dehydrogenase dependent on FAD (flavin adenine dinucleotide) can be used to determine blood glucose. A main feature of this product is that it is not influenced by the presence of maltose, galactose, or oxygen in the blood.
Pyranose oxidase can be used to measure pyranose (glucose, 1,5-AG) levels in biological and food samples. A main feature of this product is that it is highly stable in the liquid state and is not inhibited by high salt concentrations.
Amino acid oxidase
We have been developing various amino acid oxidases or oxygenase with high substrate specificity (e.g. D-amino acid, L-Tryptophan, L-Phenylalanine, Glycine and L-Kynurenine) and thermostability. These enzymes can be used for measurement of the substrate levels in samples and for production of 2-oxo acid or hydroxy derivatives.
Manufacturing services and joint development
We offer contract manufacturing services regarding such fermentation, extraction and purification.
Click here for details of our biochemical facilities.
We are also always interested in possible joint development projects for biochemical materials that meet the customers' specific application needs.